Extended Data Fig. 8: Cryo-EM structures of MPXV CorePro in complex with compound A1 and A4.
From: Substrate recognition and cleavage mechanism of the monkeypox virus core protease
a, Cryo-EM map of MPXV CorePro in complex with compound A1 (Threshold 0.4). The CorePro domains, CD, NTD and CTD are in green, blue and red/orange, respectively. A1 is depicted in deep pink. Zoomed-in view of CorePro in complex with A1 is shown on the right. A1 is represented as sticks, accompanied by a local density map (Threshold 0.32). b, Depiction of the interactions between A1 and CorePro. c, Cryo-EM map of MPXV CorePro in complex with compound A4 (Threshold 0.4). A4 is depicted in pink. The local density map of A4 on the right is set to 0.35. d, Depiction of the interactions between A4 and CorePro.
