Extended Data Fig. 1: Phylogenetic and conservation analysis of orthopoxvirus core proteases.
From: Substrate recognition and cleavage mechanism of the monkeypox virus core protease
a, Amino acid sequence alignment of core proteases from the orthopoxviruses that infect humans. Conserved residues are shaded. Residues close to the active site are boxed and labeled. b, The positions of the residues that are not fully conserved are shown as red spheres on the structure of MPXV CorePro. The positions of the catalytic triad residues are shown as yellow spheres.
