Extended Data Fig. 6: Projected secondary structure with tertiary and quaternary interactions of ROOLEfa shown based on the cryo-EM structure.

H1–H16 of monomers 1–4, H7, and H13, H15, H16 of monomers 5–8 are shown to indicate tertiary and quaternary interactions in ROOLEfa. In ROOLFirm, G-A stacking replaces G-C Hoogsteen base pairing.