Extended Data Fig. 6: Structural features of full-length TAS1R2-TAS1R3 heterodimers.
From: Structural and functional characterization of human sweet taste receptor
a, Molecular surface of the apo-state TAS1R2-TAS1R3 complex, showing the plane of heterodimer interfaces for the VFTD and TMD. Structural elements involved in heterodimer formation are highlighted in cartoon representation. b, Structural comparison of TAS1R2 and TAS1R3 in apo- and sucralose-bound states. TAS1R3 is shown as cartoon and TAS1R2 is shown as transparent surface (left). TAS1R2 is shown as cartoon and TAS1R3 is shown as transparent surface (right). c, Conformational changes of VFTDs in apo- and sucralose-bound states viewed from the extracellular top. d, The bending of CRDs in TAS1R2 and TAS1R3 from apo- to sucralose-bound states.
