Extended Data Fig. 9: Connectional input specificities of MPF areas with olfactory cortical areas and the claustrum (CLA).
a, A 2D cluster map highlights the distinct olfactory inputs to MPF areas and TTd, based on the connectivity data shown in b (for injection sites, see Extended Data Fig. 5). The brightness of the grids corresponds to strength of input. The brighter the grid, the stronger the connection. Numbers 1-4 refer to the corresponding panels of retrograde labelling in different olfactory regions in b, Note the consistency between the raw image data and the results of the clustermap. For example, strongest input to MPF from the COApm (#3) is to DPd, which is evident from both the clustermap in a and the raw image in b. c-e, Comparisons of quantified olfactory inputs to different MPF areas from the AON, PIR, and COApm, respectively. f, A summary of average projections to MPF areas from olfactory regions. Collectively, these data illustrate distinct connectivity patterns of the TTd, DPs, DPd, and other MPF areas. While TTd (as part of the olfactory cortical area) receives dense input from PIR, AON, and TTv, DPs receives dense inputs from PIR and AON. DPd uniquely receives dense inputs from COApm, in addition to other olfactory inputs. ILA receives weak olfactory inputs, while other MPF areas remain void of olfactory inputs. g, Retrograde labelling in CLA after CTB or FG injections into DPd, DPs, ILA, or PL reveals quantitatively distinct connectivity patterns shown in h, DPs receives no inputs from CLA, whereas DPd, ILA, and PL receive robust CLA input. Note the consistency between the raw and quantified datasets. See SI Fig. 7 for connectional output specificities of MPF areas with cortical areas and the CLA.
