Extended Data Fig. 15: Topographic projections of MPF to the hypothalamus.
a, Microscopic images show topographic projections from DPs, DPd, ILA, PL, ACAv, and ACAd to hypothalamus across different rostral-caudal levels (anterior, tuberal, and posterior). Note that DPd generates dense projections to the periventricular zone. The DPd and ILA generate projections to different hypothalamic nuclei in the medial zone. DPs, DPd, ILA, and PL generate dense, partially overlapping, projections to LHA, while the ACAv and ACAd project densely to the zona incerta and much less to LHA. Also see Supplementary Results section Topographic projections from MPF to LHA. b, Quantified comparison of projections from MPF areas to the preautonomic PVHd, which includes the PVHlp and PVHf. Data shows that PVHd receives input from DPs. c, Comparison of quantified projections from MPF to LHA tuberal level. Data is visualized in a pareto chart, which orders the number of projections in descending order, shows that densest projections from MPF to LHA are from DPs. The cumulative total of projections is represented by the curved line. Right y axis denotes cumulative percentage.
