Extended Data Fig. 6: p53 hyperactivity in mTECs causes systemic defects in immune tolerance.
From: Thymic epithelial cells amplify epigenetic noise to promote immune tolerance
a, Representative flow cytometry plots of T effector memory (TEM) and naïve (TN) compartments of splenic CD8+ T cells from 10 month-old p53-WT and p53-cHyper sex-matched littermates. b,c, Comparison of frequencies of indicated splenic T cell compartments between p53-WT and p53-cHyper sex-matched littermates (n = 12). P-values from two-sided paired t-tests. d, Comparison of histopathology scores (based on number and size of lymphocytic infiltrates) from the indicated organs between sex-matched littermates (n = 8) of indicated genotypes.
