Extended Data Fig. 2: Additional features resolved in sc-GATOR2.
From: Structural basis for the dynamic regulation of mTORC1 by amino acids
(a) Density representation of apo sc-GATOR2, with region of interest labeled. (b) Density representation of the unsharpened composite map indicating the position of the resolved WDR24 extension (chain D, residues 610–630). (c) Cartoon representation of the apo sc-GATOR2 model illustrating the reassignment of chains I and J from wild-type GATOR2 (PDB ID: 7UHY), which we were previously unable to assign to a GATOR2 component, to WDR59 (chain D of apo sc-GATOR2). (d) Cartoon representation of the region containing the resolved linker within sc-WDR59-SEC13. (e) Representation of the density corresponding to the resolved sc-WDR59-SEC13 linker. (f) Comparison of the sc-WDR59-SEC13 linker region from wild-type GATOR2 (PDB ID: 7UHY) and apo sc-GATOR2.
