Extended Data Fig. 1: Ex-vivo mouse colonic motility sensing.
From: High-density soft bioelectronic fibres for multimodal sensing and stimulation
a, A photograph showing the system used for ex-vivo monitoring of colonic motility. b, Motility signals recorded by one of the S-NeuroString sensors (S7) (300 µm in diameter, 5 MPa Young’s modulus) inside the colon. c, Sensor layout inside the S-NeuroString used for motility detection in the colon. d, A photograph showing the colon from Supplementary Video 2 and the locations for colon diameter measurements (X1-X8). The circles indicate the locations of pressure sensors (S1-S8). The distance between each two sensors is 0.5 cm. e, Motility signals recorded by sensors in the colon. The propagation of pressure signals from sensor 7 to sensor 4 was observed in the sensors’ output (marked with an arrow). f, The measured colon diameter from the camera video recording (Supplementary Video 2) also shows the propagation of diameter change from location X7 to X4. g, Comparison between the sensor outputs and video analysis outputs, showing high similarity in the signals, which confirms good the motility sensing provided by our fibers. All traces were normalized and shifted for clarity (see methods). h, Two examples illustrating the sensor output and camera output (diameter change with time) at diameter locations: X5/X7 and sensor locations S5/S7. The cross-correlation analysis yielded coefficients of 0.7 for X7/S7 and 0.5 for X5/S5, indicating a good level of correlation for the entire recording. Specific regions exhibit even higher similarity. For instance, the marked boxed regions in h show cross correlation coefficients (ccc) of 0.9 and 0.8 for X7/S7 and X5/S5, respectively.
