Extended Data Fig. 9: CDKN1B ablation increases the proliferation of BCMA CAR-T cells. | Nature

Extended Data Fig. 9: CDKN1B ablation increases the proliferation of BCMA CAR-T cells.

From: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

Extended Data Fig. 9

a. Comparison of cell cycle (G0/G1, S, G2/M) between CDKN1B KO and intergenic control KO CAR-T cells. Stimulation with irradiated K562-BCMA tumor cells was conducted on day 0 and day 6, with flow cytometry measurements on day 0 (before stimulation), day 1, day 7, and day 14 (schematic overview, left). *p < 0.05, and **p < 0.01.

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