Extended Data Fig. 5: Bubble plot of pathway identities and p-values extracted from suppl. Table 2 of Neyroud et al. ²⁴.

Functional annotation terms were filtered at a P-value cut-off of <0.0001 from GSE271521. Mouse muscle mRNAs were subjected to DAVID bioinformatics analysis (DAVID Functional Annotation Bioinformatics Microarray Analysis) to identify enriched biological processes/pathways. Biological process categories (left side column) represent themes of high differential expression between subtype 1 (versus subtype 2) in male patients in our clinical study sample; this specific comparison was chosen because the mice were of male sex. Size of dots represents p-value significance as depicted in the bubble plot. The color of the bubble represents different pathway categories mentioned on the left side of the figure. Results are presented based on the temporal analysis from Day 8 through to the study endpoint (Day 15–18).