Extended Data Fig. 1: Correlation between muscle change over time in lumbar, thoracic and thigh musculature.

Total muscle cross-sectional area was determined in the 3^rd lumbar vertebra, at the 4^th thoracic vertebra and thigh 11.25 mm below the lesser trochanter of the femur. Muscle change over time is expressed as % for N = 39 patients. Statistic Pearson r. Inset: cross correlations between L3, T4 and leg muscle change over time. These regions include different muscles: abdomen at L3 (rectus abdominis, lateral and oblique abdominis muscles, quadratus lumborum, psoas, paraspinal (multifidus, erector spinae), thigh (rectus femoris, sartorius, vastus intermedius, vastus lateralis, adductor, gracilis, gluteus maximus, biceps femoris and semitendinosus) and chest at the 4^th thoracic vertebra (pectoralis, external intercostal, serratus anterior, teres major, subscapularis, infraspinatus, rhomboid major, erector spinae, trapezius). The high degree of intercorrelation of muscle change over time these regions suggests that cancer-associated muscle atrophy is systemic.