Extended Data Fig. 4: Reset performance with varying cooling time.
From: Heat-rechargeable computation in DNA logic circuits and neural networks
a, Fluorescence kinetics experiments of resetting a DNA catalyst by heating to 95 °C for 5 minutes and then cooling to 20 °C in 1, 12.5, 37.5 and 75 minutes. The input was inactivated by adding an inhibitor (a strand with complementary sequence) at the same concentration as the input. Standard concentration 1 × = 100 nM. b, Comparison of baseline output concentration without any input before and after reset. Two replicated trajectories after reset are taken from the experiment with 0 × input in the second and third plots in (a). c, Simulations and experimental data of reset success rate indicated by the baseline output concentration after reset. Average of the first 5 data points from the two replicated trajectories in (b) are shown in the bar chart. d, Simulations of reset success rate with up to 10 days of cooling time and with varying concentration.
