Fig. 6: Reusable Fibonacci logic circuit.
From: Heat-rechargeable computation in DNA logic circuits and neural networks
a, Logic circuit diagram. Because the ith and (i + 8)th elements are identical, the most significant bit x1 in the 4-bit input is not connected to any logic gates. b, DNA circuit diagram. A dual-rail technique was used; each signal was replaced by a pair of signals representing logic on and off separately, whereas each logic gate was combined with its upstream NOT gates and translated into a pair of AND and OR gates. Five types of species were involved, and one example of each is shown. c, Simulations and fluorescence kinetics experiments for 16 rounds of computation with all possible input combinations. The simulations indicate the expected circuit behaviour without the impact of reset. To preserve the generality and predictive power of the simulation, common rate constants and nominal concentrations were used to model the reactions involved in all logic gates. The difference between the simulations and experiments was probably because of the impact of varying sequences and effective concentrations across distinct circuit components. The DNA sequences are listed in Supplementary Table 9.
