Extended Data Fig. 5: Loss of Spp1 inhibited PDAC development and metastasis formation.
From: SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
a, H&E and immunohistochemistry of Krt19 in tumors from KPhetFCT; Spp1wt/wt and KPhetFCT; Spp1fl/fl mice. n = 3 mice. Scale bar: 2.5 mm. b, Immunofluorescence staining for GFP (gray), Krt19 (green), and Vimentin (red) of KPhetFCT; Spp1wt/wt and KPhetFCT; Spp1fl/fl tumours. n = 3 mice. Scale bar: 50 μm. c, H&E and immunohistochemistry for Vimentin in livers from KPhetFCT; Spp1wt/wt (n = 15 mice) and KPhetFCT; Spp1fl/fl mice (n = 20 mice). Scale bar: 10 mm. d, H&E and immunohistochemistry for Vimentin in lungs from KPhetFCT; Spp1wt/wt (n = 15 mice) and KPhetFCT; Spp1fl/fl mice (n = 20 mice). Scale bar: 5 mm.
