Extended Data Fig. 14: Additional assessments of the behavioural consequences of Adrb1-OE mice.
From: The astrocytic ensemble acts as a multiday trace to stabilize memory
a, Graphs showing no alteration in locomotion of Adrb1-OE mice during the open field test. Ctrl: n = 13 mice, Adrb1-OE: n = 14 mice. Two-way ANOVA and Šídák’s multiple comparisons test were used. b, Graphs showing no alteration in time spent in center zone of Adrb1-OE mice during the open field test. Ctrl: n = 13 mice, Adrb1-OE: n = 14 mice. Mann-Whitney test. c-k, Minute-by-minute freezing behaviour of Ctrl and Adrb1-OE mice across conditioning and recall sessions. After three-shock FC (c), freezing was measured during the 1st (d) and 2nd FR (e). After one-shock FC (f), freezing was measured during the 1st (g) and 2nd FR (h), with Adrb1-OE mice showing significantly more freezing. In a separate three-shock FC cohort (i), freezing was measured during the 1st FR (j) and CtxB exposure (k), where Adrb1-OE mice also showed increased freezing. n = 5–7 mice per group (c–e), 13 per group (f–h), and 13–14 per group (i–k). Two-way ANOVA with Šídák’s test. Data are mean ± SEM. *p < 0.05; ns, not significantly different. Sample sizes and replicates in Supplementary Table 1.
