GRAPE-LM (generator of RNA aptamers powered by activity-guided evolution and language model) is a generative AI framework that enables the one-round generation of short RNA binders. When guided by CRISPR–Cas-based intracellular screening, GRAPE-LM outperforms traditional multi-round methods for aptamer evolution.
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References
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This is a summary of: Zhang, J. et al. Single-round evolution of RNA aptamers with GRAPE-LM. Nat. Biotechnol. https://doi.org/10.1038/s41587-026-03007-5 (2026).
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Generative AI powered by nucleic acid language model enables one-round evolution of RNA aptamers. Nat Biotechnol (2026). https://doi.org/10.1038/s41587-026-03008-4
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DOI: https://doi.org/10.1038/s41587-026-03008-4
