Fig. 7: Higher density of Pik3ca MMs in overweight humans.
From: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus
Human donors were classified into overweight, OW–OB (n = 10, BMI ≥25 kg m−2) and non-OW (n = 8, BMI <25 kg m−2). PIK3CA MMs were classified as Path/GoF and Unkn/NE (Methods) and analyzed separately in OW–OB and non-OW donors. a, The number of clones per centimeter squared carrying PIK3CA MM Path/GoF (top) or Unkn/NE (bottom) plotted against donor age. Each dot represents a donor. Simple linear regression for OW–OB and non-OW donors is shown. Tukey’s test. b, Representative patchwork plots. Each panel is a representation of PIK3CA mutant clones in an average 8 cm2 area of esophagus from non-OW (top) or OW-OB (bottom) donors. To generate each figure, a sample of biopsies from all donors >60 years of age was randomly selected from each weight category amounting to 8 cm2 of tissue. All PIK3CA mutant clones are represented as circles and randomly distributed in space.
