Extended Data Fig. 3: PCA and permuted energy distance test. | Nature Genetics

Extended Data Fig. 3: PCA and permuted energy distance test.

From: Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification

Extended Data Fig. 3

a, Individual gene ranking of PC1. b, variance ratio of PCA. c, Bona-fide monocyte and macrophage signature score in UMAP projection. d, scatter plot of the energy distance against the number of differentially expressed genes (DEG) calculated as pairwise comparison to NTC. Each dot represents a perturbation. Perturbations with significant effects (energy distance; FDR < 0.01, DEGs; FDR < 0.05) indicated in blue, non-significant in red. e, cluster map of cosine similarity between perturbations. Rows and columns are hierarchically clustered. Perturbations with significant effects as determined in (d) indicated in blue, non-significant in red.

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