Fig. 2: scRNA-seq of desmosome gene expression in human melanomas.
From: Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation
a, Tumor biopsies from two patients, one male and one female, processed using scRNA-seq. b, UMAP analysis of 1,109 individual cells from melanoma 1, with the color indicating the inferred cell type. ‘Cancer’ denotes melanoma cells. The two clusters of keratinocyte cells (red) reflect basal versus non-basal types. c, Same UMAP as in b, with the color indicating the expression of desmosome genes as median transcripts per million (TPM) (Online Methods). d, Correspondence of desmosome gene expression to cell types. The color indicates the mean expression per cell (log2). The dot size indicates the fraction of cells in the cell type expressing each desmosome gene.
