Extended Data Fig. 4: Comparison of the structures of ribosome-bound macrolones, macrolide erythromycin and tetracenomycin X. | Nature Chemical Biology

Extended Data Fig. 4: Comparison of the structures of ribosome-bound macrolones, macrolide erythromycin and tetracenomycin X.

From: Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms

Extended Data Fig. 4

(a, b) Superposition of the structure of ribosome-bound MCX-66 (magenta), MCX-91 (green), MCX-128 (yellow) with the previous structures of ERY (red, PDB entry 6XHX ref. 15), or TcmX (blue, PDB entry 7ZTA ref. 75). All structures were aligned based on domain V of the 23S rRNA.

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