Extended Data Fig. 3: Electron density maps of ribosome-bound MCX-66, MCX-91, and MCX-128.
From: Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms
(a-c) 2Fo-Fc Fourier electron density maps of MCX-66 (a, magenta), MCX-91 (b, green), and MCX-128 (c, yellow) in complex with the T. thermophilus 70S ribosome (blue mesh) shown in two mutually perpendicular views. The refined models of ribosome-bound MCX compounds are displayed in their respective electron density maps after the refinement contoured at 1.0σ. Carbon atoms are colored magenta (MCX-66), green (MCX-91), or yellow (MCX-128); nitrogen atoms are blue; oxygen atoms are red; fluorine atoms are dark green. Note that the locations of fluoroquinolone side chains can be unambiguously determined from the obtained electron density maps.
