Extended Data Fig. 7: Characterization of Ubr5 and Vgll4 expression pattern in cholangiocytes during liver development.
From: Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis
a, The liver samples from E13.5, E18, P0 and P21 mice were stained for Ubr5 (red), Sox9 (green) and DAPI (blue) and then subjected to confocal imaging. A representative result of three independent experiments is shown. Scale bar, 100 μm. b, Percentage quantification of Ubr5-positive ductal cells during liver development as shown in a. Data were represented as mean ± s.d. (n = 3 biological replicates). c, Scheme of the Ubr5/Vgll4 expression pattern during liver development. d, The liver samples from E13.5, E18, P0 and P21 mice were stained for Vgll4 (green), Sox9 (red) and DAPI (blue) and then subjected to confocal imaging. A representative result of four independent experiments is shown. Scale bar, 100 μm. Magnification = ×2. e, Percentage quantification of Vgll4 positive ductal cells during liver development as shown in d. Data were represented as mean ± s.d. (n = 4 biological replicates).
