Supplementary Fig. 7: Therapeutic effect of 441D6 in mouse infection model.
From: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
Therapeutic administration of control VRC01 (anti-HIV) and 441D6 monoclonal antibodies in mice infected with A/California/07/2009 (H1N1) (a) or A/Puerto Rico/8/1934 (H1N1) (b). BALB/c mice were intranasally infected with a 10 × LD50 of either H1N1 viruses 24 hours before receiving monoclonal antibodies via intraperitoneal injection. Clinical symptoms and body weight were monitored throughout the study. Lines in plots showing body weight change indicate mean of group with standard deviations including only live animals at indicated time points. Experiment was performed once (n = 10).
