Fig. 8: Model of immunosubversion approach with mosaic antigen array.
From: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
a, B cell activation by homotypic or heterotypic antigen arrays. B cells possessing BCRs specific to ‘gray’ antigen or cross-reactive to multiple antigenic variants are colored gray or orange, respectively. Situations with particulate stimuli (for example, virus, vaccine, etc.) made of homotypic (left) or heterotypic (right) antigens are shown. b, Predicted immune outcome induced by homotypic (top) and heterotypic (bottom) antigen arrays.
