Fig. 7: OSM signaling in epithelial cells promotes leukocyte recruitment.
From: The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis
a, Venn diagram representing the overlap of differentially expressed genes in epithelial bulk and scRNA-seq datasets from Fig. 6a,d. b, Significantly enriched (adjusted P < 0.05) Gene Ontology terms of the overlapping genes from both comparisons in Fig. 6a,d; adjusted P values were calculated using the Benjamini–Hochberg test. c, GSEA plot depicting the enrichment of differentially expressed genes from pathways related to cell chemotaxis in epithelial cells comparing inflamed IECΔOsmr and control mice, as in Fig. 6d. d, H. hepaticus + anti-IL-10R colitis was induced in IECΔOsmr (n = 13) and control mice (n = 11). The immune cell composition in the lamina propria was analyzed by flow cytometry on day 21 of inflammation. Data are representative of two independent experiments. P values (two-tailed) were calculated using a Mann–Whitney U-test comparing IECΔOsmr and control mice.
