Extended Data Fig. 7: Enriched C6 gene sets in Keap1-/- versus WT P14 cells and mass spectrometry validation of PTGIR peptides.
From: The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion
(a) Top 10 enriched pathways for MSigDB C6 (oncogenic signature) gene sets in Keap1-/- versus WT P14 T cells following LCMV infection (7 dpi). Data are plotted as Normalized Enrichment Score (NES) for each pairwise comparison. (b) Representative PRM transition traces for the synthetic (top) and endogenous (bottom) PTGIR peptides GFTQAIAPDSR and (c) EMGDLLAFR. (d) Representative MS2 spectra of the synthetic (top) and endogenous (bottom) peptides (from b) GFTQAIAPDSR and (from c) EMGDLLAFR of PTGIR.
