Dendritic cell (DC) heterogeneity underpins effective immune responses, but subset definition is complex. Zhu et al. delineate the development of type 2 conventional DCs and plasmacytoid DCs in mice, defining distinct ontogenies and transcription factor dependencies that provide a framework for unifying DC subset classification.
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Bigley, V., Collin, M. 2B or not 2B is the question in DC ontogeny. Nat Immunol 26, 1214–1216 (2025). https://doi.org/10.1038/s41590-025-02220-9
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DOI: https://doi.org/10.1038/s41590-025-02220-9
