Fig. 2: Diverse pathogen infection tailors B cell responses. | Nature Immunology

Fig. 2: Diverse pathogen infection tailors B cell responses.

From: Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

Fig. 2

a–d, Analysis of draining lymph node cells (a–c) and serum (d) from wild-type (a,b) and ZsGreen_T-bet (c) reporter mice infected with the indicated pathogens at the early peak GC response. Analysis of B220+IgDloCD95+CD38− GC B cells (a) and B220+IgDloCD95−CD38+ MBCs (LCMV n = 8; influenza n = 8; T. muris n = 6; H. polygyrus n = 9; and C. rodentium n = 8 mice per group) (b). Correlation of the frequency of MBC with the ratio of Teff:TFH cells and ZsGreen_T-bet reporter expression gMFI across infections (c). Serum IgG isotype concentration (d). The data are from 6–10 mice per group and are presented as the mean ± s.e.m. Statistical tests included one-way ANOVA for multiple comparisons and Pearson correlation with two-tailed P values. ****P < 0.0001 or otherwise indicated.

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