Fig. 3: B cells sustain retention of lean mass in mice given TNFΔARE/+ BM.
From: Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
a, Weekly percent weight change in mice given WT, μMT, TNFΔARE/+ or μMT-TNFΔARE/+ BM normalized to weight 2 weeks post-BMT (six independent experiments, WT (n = 24), μMT (n = 9), TNFΔARE/+ (n = 22), μMT-TNFΔARE/+ (n = 23)). b–f, Mice given WT, TNFΔARE/+ and μMT-TNFΔARE/+ BMT after 14 weeks (three independent experiments, WT and TNFΔARE/+ (n = 14) and μMT-TNFΔARE/+ (n = 13)). b, EchoMRI evaluation of the body composition of mice given WT, TNFΔARE/+ or μMT-TNFΔARE/+ BM. c, Core body temperature of mice given WT, TNFΔARE/+ or μMT-TNFΔARE/+ BM. d–f, Mice were housed in metabolic cages for 24 h, and activity (d), heat (e) and food intake (f) were measured. g, Weight of the gastrocnemius muscle in BM recipients (three independent experiments, WT (n = 13), TNFΔARE/+ (n = 14) and μMT-TNFΔARE/+ (n = 12)). h, Micro-CT analysis of paws of the bone mineral density (three independent experiments WT and μMT-TNFΔARE/+ (n = 14), TNFΔARE/+ (n = 13)). All data represent mean ± s.e.m. One-way ANOVA with post hoc Tukey test in c, g and h; two-way ANOVA (to test whether light versus dark is different in addition to whether there are group differences) in d–f.
