Extended Data Fig. 2: B cells protect against weight loss in TNFΔARE/+ mice.
From: Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
a-g: WT, TNFΔARE/+, and μMT-TNFΔARE/+ BM recipients 14 weeks post-transplant. a: Body weight of the mice at week 14. Mice were housed in metabolic cages for 24 h and scatterplots show energy expenditure (b), food intake (c), and water intake (d,e), quantified in the metabolic cages (d), and charted against body weight (e). Hydration ratio of the mice, measured by MRI, calculated as (total water - free water) / lean weight. f,g: Paws collected from WT, TNFΔARE/+, and μMT-TNFΔARE/+ BM recipients 16–17 weeks post-transplant showing the percentage of bone volume over total volume (f) and bone surface area over bone volume (g). (Three independent experiments WT and TNFΔARE/+ (n = 14), μMT-TNFΔARE/+ (n = 13)). For a, d-g data represent mean ± SEM. For b,c, lines and shaded areas represent a linear regression model fit per group. Each symbol represents a single mouse. One-way ANOVA with Tukey post-hoc test (a, e-g), Two-way ANOVA on d.
