Table 1 Phenotypic and molecular characterization of human T-ALL samples

Sample	EGIL classification	CD3^loTCR^neg	cTCRβ	PTCRA mRNA^a	TCRVβ^a	ICN1^a
T-ALL1	Mature	−	+^a	+/−	TRBV12-4	−
T-ALL2	Cortical	−	+^a	+	TRBV12-3	+
T-ALL3	Pre-T	+	+^a	+	TRBV19	+
T-ALL4	Cortical	+	ND	ND	ND	ND
T-ALL5	Cortical	+	+^a	+	TRBV7-9	+
T-ALL8	Mature	−	+^a	−	TRBV20-1 TRBV7-9	+
T-ALL9	Cortical	+	+^a	+	TRBV28	+
T-ALL10	Pre-T	−	+^a	−	TRBV28	+
T-ALL17	Pre-T	+	+^a	+	TRBV5-1	+
T-ALL18	Cortical	+	ND	ND	ND	+
T-ALL21	Cortical	+	+^a	+	−	+
T-ALL23	Pre-T	+	+^a	+	TRBV12-3	−
T-ALL26	Pre-T	−	+^a	+	TRBV6-3	+
T-ALL29	Cortical	+	+^a	+	TRBV27	+
T-ALL32	Mature	−	−^a	−	−	−
T-ALL36	Cortical	−	+^a	+/−	TRBV7-2 TRBV7-4	+
T-ALL37	Pre-T	−	+^a	−	−	ND
T-ALL39	Cortical	+	ND	ND	ND	ND
T-ALL40	Cortical	−	+^a	+/−	TRBV2	+
T-ALL41	Cortical	−	+^a	+/−	TRBV6-6	−
T-ALL42	Cortical	+	+^a	+	TRBV20-1	+
T-ALL43	Cortical	+	+^a	+	TRBV3-1 TRBV6-4	+
T-ALL49	pre-T	+	+^a	+	TRBV28	−
T-ALL56	Cortical	+	+^a	+	TRBV5-6	−
T-ALL57	Mature	−	−^a	−	−	−
T-ALL60	pre-T	−	−	ND	ND	ND
T-ALL61	Mature	−	+/−	ND	ND	ND
T-ALL62	pre-T	+	+	ND	ND	ND
T-ALL63	pre-T	−	+	ND	ND	ND
T-ALL64	ETP	−	+	ND	ND	ND
T-ALL65	Cortical	+	+	ND	ND	ND
T-ALL66	Cortical	+	+	ND	ND	ND
T-ALL67	pre-T	+	+	ND	ND	ND
T-ALL68	pre-T	+	+	ND	ND	ND
T-ALL69	Cortical	+	+	ND	ND	ND
T-ALL70	pre-T	+	+	ND	ND	ND
T-ALL71	pre-T	+	+	ND	ND	ND

CD3^loTCR^neg and cTCRβ were determined by surface and intracellular flow cytometry, respectively; PTCRA mRNA by quantitative PCR (Extended Data Fig. 1a); and ICN1 by immunoblotting. ND, not determined. ^aNSG-propagated.

Quick links

Search