Extended Data Fig. 5: The analysis of transcriptional heterogeneity in human pDCs.
From: Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells
A previously reported scRNA-seq dataset of pDCs from peripheral blood of three healthy human donors (GSE189120) was reanalyzed to assess steady-state heterogeneity. (a) KNetL and UMAP plots, with KNetL-based human transcriptome (Ht) clusters indicated. (b) Violin plots showing transcript levels of key pDC identity genes by KNetL clusters. (c) KNetL plots of Ht clusters, split up by individual donor. (d) Heatmap of marker gene expression for KNetL clusters.
