Extended Data Fig. 5: Shared and differentially expressed genes between YP and AYA cell clusters. | Nature Immunology

Extended Data Fig. 5: Shared and differentially expressed genes between YP and AYA cell clusters.

From: Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Extended Data Fig. 5

a) Heatmap showing the overlap of differentially expressed genes between pairs of cell types from CITE-seq data of BM aspirates of YP donors (n = 4, age 2.1-9.6 years, 2 males, 2 females). b) As in a), but for AYA donors (n = 3, age 13.3-16.7, 1 male, 2 female). Abbreviations: YP, young pediatric; DE, differentially expressed; AYA, adolescent and young adults. HSC, hematopoietic stem cell; LMPP, lympho-myeloid primed progenitor; MEP, megakaryocyte-erythroid progenitor; MkP, megakaryocyte progenitor; EryP, erythroid progenitor; McP, mast cell progenitor; LyP, lymphoid progenitor; TN, naive T cell; TM, memory T cell; Treg cell, regulatory T cell; MAIT cell, mucosal-associated invariant T cell; NK cell, natural killer cell; progDC, dendritic cell progenitor; cDC, conventional DC; pDC, plasmacytoid DC; Ery, erythroid cell; DC, dendritic cell; MSC, mesenchymal stromal cell.

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