Extended Data Fig. 2: External references validate cell type annotations and multimodal clustering. | Nature Immunology

Extended Data Fig. 2: External references validate cell type annotations and multimodal clustering.

From: Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Extended Data Fig. 2

a) Tile plots showing mapping of each of the 28 cell clusters in the CITE-seq dataset (n = 9 donors, age 2.1-31.3, 3 male, 5 female) to the external dataset of Stuart et al.18. Colors depict the proportion of cells in each cluster assigned to each reference cell type. b) As in a), but for the external DISCO single-cell reference map19. HSC, hematopoietic stem cell; LMPP, lympho-myeloid primed progenitor; MEP, megakaryocyte-erythroid progenitor; MkP, megakaryocyte progenitor; EryP, erythroid progenitor; McP, mast cell progenitor; LyP, lymphoid progenitor; TN, naive T cell; TM, memory T cell; Treg cell, regulatory T cell; MAIT, mucosal-associated invariant T cell; NK, natural killer cell; prog DC, dendritic cell progenitor; cDC, conventional DC; pDC, plasmacytoid DC; MSC, mesenchymal stromal cells; LMPP, lymphoid-primed multipotent progenitor; Prog_Mk, megakaryocyte progenitor; Prog_RBC, red blood cell progenitor; GMP, granulocyte-monocyteprogenitor; Mono, monocyte; Prog_DC, dendritic cell progenitor; MPP, multipotent progenitor; CMP, common myeloid progenitor; CLP, common lymphoid progenitor; ILC, innate lymphoid cell; CDP,common dendritic cell progenitor; cDC1, conventional DC type 1; cDC2, conventional DC type 2; pre-pDC, precursor plasmacytoid DC.

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