Extended Data Fig. 3: Spatial transcriptomics validates age-dependent differences in BM composition between YP and AYA. | Nature Immunology

Extended Data Fig. 3: Spatial transcriptomics validates age-dependent differences in BM composition between YP and AYA.

From: Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Extended Data Fig. 3

a) Representative BM cores from each individual showing the spatial distribution of major cell populations within the biopsy sections. Scale bar = 300 μm. b) Stacked bar plots showing the relative abundance of major BM cell populations within the biopsy sections. c) as in b), but at the subset level. Abbreviations: HSPC, hematopoietic stem and progenitor cell; NK cell, natural killer cell; MSC, mesenchymal stromal cell; SEC, sinusoidal endothelial cell; AEC/VSMC, arterial endothelial cell or vascular smooth muscle cell; EryP, erythroid progenitor cell; BaEoMaP, progenitors of basophils, eosinophils and mast cells; MkP/Mk, megakaryocyte progenitor cell or megakaryocyte; pDC, plasmacytoid dendritic cell; Adipo-MSC, adipolineage MSC; Fibro-Osteo-MSC, fibro-osteolineage MSC; Fibro-MSC, fibrolineage MSC; Osteo-MSC, osteolineage MSC; YP, young pediatric; AYA, adolescents and young adults.

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