Extended Data Fig. 5: SIV Gag-specific T-cell responses. | Nature Medicine

Extended Data Fig. 5: SIV Gag-specific T-cell responses.

From: A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Extended Data Fig. 5

Induction of SIV Gag-specific CD4+ and CD8+ T-cell responses in all 7 vaccinated macaques at weeks 27 and 60 of immunization. a. Gag-specific CD4+ T-cell responses calculated as fractions of memory CD4+ T cells expressing CD154 and the indicated intracellular cytokines or CD69. b. Gag-specific CD8+ T-cell responses calculated as fractions of memory CD8+ T cells expressing CD69 and the indicated intracellular cytokines or CD107. c. Correlation between a subset of Env-specific T-follicular helper cells (CXCR5+CXCR3-PD-1+) and protection in vaccinated macaques. The correlation was statistically significant after exclusion of a single outlier (macaque V7, highlighted in red). The correlation coefficient and P value with the inclusion of the outlier are indicated in red.

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