Extended Data Fig. 7: Epitope mapping of trimer-binding antibodies in serum from vaccinated macaques. | Nature Medicine

Extended Data Fig. 7: Epitope mapping of trimer-binding antibodies in serum from vaccinated macaques.

From: A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Extended Data Fig. 7

a. Competition with HIV-1 bNAbs, as assessed by ELISA on lectin-captured HIV-1 BG505 SOSIP.664 trimers. b. Competition with macaque monoclonal antibodies directed against off-target and non-bNAb-target regions (RM20A3, RM20C, RM20E1, RM20F, RM20G, RM20J, RM15E and RM54B1). TB: trimer base; GH: glycan holes; V1: V1 loop; FP: fusion peptide.

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