Extended Data Fig. 2: Induction of trimer-binding antibodies in the two subgroups of immunized macaques over time. | Nature Medicine

Extended Data Fig. 2: Induction of trimer-binding antibodies in the two subgroups of immunized macaques over time.

From: A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

Extended Data Fig. 2

Subgroup 1 received 5 mRNA and 5 protein immunizations; subgroup 2 received 8 mRNA and 2 protein immunizations. a. Serum titers of antibodies binding to the autologous trimer as assayed by ELISA using the WITO SOSIP.664 trimer captured on lectin-coated plates. b. Serum titers of antibodies binding to the autologous V3 loop peptide (WITO pV3) as assayed using the linear WITO V3 peptide directly coated on the plate surface. c. Serum titers of antibodies binding to a heterologous trimer (AD8) as assayed by ELISA using the AD8 IP trimer captured on lectin-coated plates. Statistical differences were calculated using a paired two-tailed t-test. The sequence and timing of immunizations are indicated by color-coded triangles on the top.

Back to article page