Extended Data Fig. 5: Increased Age and Inflammation at Screening and CDI Recurrence Prediction. | Nature Medicine

Extended Data Fig. 5: Increased Age and Inflammation at Screening and CDI Recurrence Prediction.

From: Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection

Extended Data Fig. 5

A, Concentration of cytokines predictive of on-study CDI recurrence at Screening in VE303 recipients with recurrence (n = 12) and without recurrence (n = 32); permutation importance < 0.1, frequency > 0.25 over 100 iterations of a random forest regression model. B, Box-and-violin plots showing age of participants in the VE303-dosed groups; with recurrence (n = 14) and without recurrence (n = 42). C, Correlations between MIP-1β concentrations at baseline and participant age. The blue line indicates the fit from a linear model, while the shaded region indicates the 95% confidence interval for predictions from a linear model. The box-and-whisker plots depict the median, inter-quartile range [IQR] (at the top and bottom of the boxes), and reasonable extreme values at 1.5x IQR.

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