Fig. 3: Symptom response.

a, Absolute change in TSS score from baseline at week 24; patients without week 24 data are not shown. Change from baseline was determined by ANCOVA model using multiple imputation. Least square mean difference was determined from the ANCOVA model using baseline DIPSS, baseline platelet count and baseline spleen volume as factors and baseline TSS as covariate, performed two-sided Cochran–Mantel–Haenszel test at the alpha level 5%. b, Percentage change in TSS score from baseline at week 24, overlaid with the proportion of patients experiencing a TSS50 response. Patients without baseline and week 24 data are not shown. Difference between treatment arms was compared by stratified Cochran–Mantel–Haenszel test (performed two-sided Cochran–Mantel–Haenszel test at the alpha level 5%; weighted 95% CI adjusted across strata).