Extended Data Fig. 6: Allogenic HSCT eradicates UBA1mut cells.
From: Mechanisms of hematopoietic clonal dominance in VEXAS syndrome
a, Schematic representation of the allo-HSCT experiment in the VEXAS model. b, Percentage of human cells in the BM of hematochimeric VEXAS mice treated or not with busulfan chemotherapy and donor-derived HSPC transplantation (n = 4/group). Median with IQR. c, Percentage of GFP+ (that is, donor-derived) cells within human cells in the BM of mice from b (n = 4/group). The red line indicates the percentage of GFP+ HSPCs in the donor input. Median with IQR. d, Percentage of UBA1mut cells within hematopoietic lineages in mice from b (n = 4/group). Median with IQR. Panel a created with BioRender.com.
