Extended Data Table 2 Missing data analysis

From: Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial

  1. Primary outcome at 3 months after randomization. Missing data were imputed according to the pre-specified statistical analysis plan. The imputation models included baseline values of the respective outcomes, all variables intended for the subgroup analyses (variables dichotomized for the subgroup analyses were included as continuous in the imputation model) and the advised fluid regimen prior to randomization. Imputation was performed separately by treatment arm.
  2. Unadjusted mean (95% confidence interval) or adjusted mean difference (95% confidence interval).
  3. KCCQ-OSS = Kansas City Cardiomyopathy Questionnaire Overall Summary Score; TDS-HF = Thirst Distress Scale for patients with HF.
  4. †Based on the adjusted mean difference tested two-sided with ANCOVA analysis using baseline value as covariate.
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