Extended Data Fig. 6: Nonsynonymous Variants in Post-Treatment Isolate Genomes.

Circular plots showing the distribution of variants in the post-treatment isolate genomes for the patients not shown in Fig. 3. Concentric circles represent single isolate genomes. Gray lines represent nonconservative variants that appear in coding sequences in one or more post-treatment isolates but are absent from all pre-treatment isolates. Yellow lines represent nonsynonymous polymorphisms coincident with genes expected to be under selection by the phage used in treatment. Red lines represent frameshifts for the same genes. Labeled, colored arrows indicate the positions and functional categories of these genes. Vertical black lines represent the genome start in the PAO1 reference against which variants were called.