Extended Data Fig. 1: Immunofluorescence images of representative pre-infusion tumor samples. | Nature Medicine

Extended Data Fig. 1: Immunofluorescence images of representative pre-infusion tumor samples.

From: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial

Extended Data Fig. 1

Patient slides demonstrated a range of target staining, including tissue with subjective positivity for both targets (16321-04, 16321-40, 16321-23, 16321-52), for EGFR (16321-18), and for IL13Ra2 (16321-11). Given the trial inclusion criterion of EGFR amplification, the negative staining for EGFR seen in 16321-11 is a relevant example of CAR target spatial heterogeneity. All images taken at 20x magnification. Experiments were performed in duplicate.

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