Extended Data Fig. 4: Symptom-Specific Biomarkers - Immune, KEGG and Metabolome Models.

By linking omics profiles to clinical symptoms, BioMapAI identified unique symptom-specific biomarkers in addition to disease-specific biomarkers (Extended Data Fig. 3). Each omics has a circularized diagram (Fig. 3a, Extended Data Fig. 4b–d) to display how BioMapAI use this omics profile to predict 12 clinical symptoms and to discuss the contribution of disease- and symptom-specific biomarkers. Detailed correlation between symptom-specific biomarkers and their corresponding symptoms is in Extended Data Fig. 5. a, Examples of Sleeping Problem-Specific Species’ and Gastrointestinal-Specific Species’ Contributions. Supplemental information for Fig. 3d, which shows the contribution of pain-specific species. b-d, Circularized Diagram for Immune, KEGG and Metabolome Models. Supplemental information for Fig. 3a, which shows the species model. e-f, Zoomed Segment for Pain in KEGG and Metabolome Model. Supplemental information for Fig. 3b, which shows the zoomed segment for pain in the species and immune models. *Note, the reported biomarkers were calculated using the entire dataset and were not validated on held-out data. Abbreviations and Supporting Materials: Extended Data Fig. 5. Related to: Fig. 3.