Extended Data Fig. 8: Composite model.

a. Median deviance versus log of penalty parameter from 50 repeated random iterations of five-fold cross validation. Error bars represent the median ± the standard deviation across the 50 repeats of cross-validation. b. Model performance by arm. Performance metrics were estimated from 50 repeated random iterations of an outer loop of 10-fold cross-validation. c. Partial-effect plots for continuous-valued predictors in composite model. The y-axis scale matches that for the partial-effect plots from the single-biomarker models to facilitate comparisons.