Extended Data Fig. 3: CD8 topology and 19-FTBRS GES tertiles.

a. Frequency of CD8 topology categories by patient population. b. Distribution of CD8 digital IHC scores by CD8 topology category (n = 445). Curves show mirrored Gaussian kernel density estimates. Boxes extend from the first to third quartiles, middle lines show medians, and whiskers extend to the most extreme data point that is no more than 1.5 times the IQR from the box. c. Kaplan–Meier curves by treatment arm and CD8 topology category. Shaded areas indicate 95% CI. d. Distribution of 19-FTBRS GES scores by CD8 topology category (n = 222). Plot shows first quartile, median, and third quartile, with bars representing 1.5 × IQR. e. Kaplan–Meier curves by 19-FTBRS GES score tertile and treatment arm, for CD8 desert topology. f. Kaplan–Meier curves by 19-FTBRS GES score tertile and treatment arm, for CD8 excluded topology. g. Kaplan–Meier curves by 19-FTBRS GES score tertile and treatment arm, for CD8 inflamed topology.