Fig. 2: Glucose spike metrics in the PROGRESS cohort.

a–f, Glucose spike metrics box plots: mean glucose level, defined as the average of glucose values over the entire tracking period (a); expected maximum spike relative value, defined as the maximum spike value relative to the baseline, averaged across different days (b); percentage of time spent above 150 mg dl⁻¹ (c); spike resolution, defined as the time required to absorb 50% of the glucose spike, averaged across all glucose spikes (d); expected daily number of spikes, defined as the daily number of glucose spikes, averaged across different days (e); and nocturnal hypoglycemia, defined as the average minimum glucose value occurring between 24:00 and 7:00, averaged across different days (f). The glucose spike metrics are reported by stratifying them based on self-reported diabetes status (normoglycemia, n = 174; prediabetes, n = 79; T2D, n = 94). The boxes represent the interquartile range, the vertical lines are the median values, and the whiskers show the 5th and 95th percentiles.