Extended Data Fig. 9: Comprehensive Analysis of Causal Relationships between eGFR, SBP, DBP, LDL-C and HDL-C.
From: The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health
(a) Causality evaluation using GSMR between eGFR and SBP/DBP GWAS. This panel illustrates the evaluation of causality between eGFR and SBP/DBP GWAS using the GSMR method. (b) This panel shows the bidirectional causal relationships between eGFR and SBP/DBP with their respective beta coefficients and p-values. (c) Causality evaluation using GSMR between eGFR and LDL-C/HDL-C/TG GWAS: This panel illustrates the evaluation of causality between eGFR and LDL-C/HDL-C/TG GWAS using the GSMR method. (d) This panel shows the bidirectional causal relationships between eGFR and LDL-C/HDL-C/TG with their respective beta coefficients and p-values. The intensity of the blue color represents the magnitude of the negative beta values. The thickness of the arrows is proportional to -log10(p-value), which reflects the statistical significance. GSMR, generalized summary-data-based Mendelian randomization.
